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“The Dope Science Show” Talks Xickle for Sickle Cell Awareness Month

September 25, 2017 by Andrea
Dope Science Show

Photo: CreateHer Stock



A few months ago, Dr. Eric Coles -- co-owner of Xickle RBC-Plus -- sat down with Stephany of "The Dope Science Show" to discuss sickle cell disease, how natural ingredients can be used to lessen SCD crises, and what advice he'd give to aspiring scientists, among other things. And just in time for Sickle Cell Awareness Month, Dr. Coles's episode has dropped.

Currently, Dr. Coles is working with his business partner Dr. Robert Swift developing a new drug for the treatment of sickle cell. SCD-101, as it's called, is the drug formulation of the current supplement (Xickle RBC-Plus) and has completed Phase l clinical trials, published those results (Click to read the article in the Journal Blood) and is currently in Phase ll clinical trials right now. The science of this development isn't all that new, though; it's actually based on Niprisan/Nicosan -- the drug used to treat sickle cell in Nigeria that, unfortunately, is no longer on the market.

"That's kinda the sad part of the story," Dr. Coles says. Apparently, back in 2003, the Nigerian version of the FDA approved the drug in Nigeria and licensed Niprisan to a U.S.-based pharmaceutical development company for the purpose of producing the drug as an FDA-approved one. But, before the U.S. company could develop anything, it went bankrupt. Around the same time, in Nigeria, the bank foreclosed on the facilities that produced Niprisan. All those with sickle cell that were taking Niprisan could not longer get their treatment. 

Soon after, Dr. Swift, decided to take on the development of Niprisan himself. He did so alone from 2009 to 2011, when Dr. Coles joined him. Together, they have improved the formulation with more anti-sickling activity and have commenced clinical trials. So far the results have been excellent.

Listen to the entire podcast below to learn even more:


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